AMB Volume 35, Issue 2, 2019 Pages 46-52
Antiviral Activity of Dipyridamole in Experimental Viral Infections in Mice
Mastikova, M., Galabov, A.S., Karparov, A.A., Doseva-Runevska, P.
Single application of the interferon inducer dipyridamole administered intraperitoneally or per os demonstrated a marked antiviral effect in mice with experimentally induced alphavirus infection –Semliki Forest (SFV) virus-caused encephalitis, applied orally in influenza virus A/Puerto Rico/8/34 (H1N1) and B/Lee/40 – respiratory infections, and herpes simplex virus type 1, strains Lennett and Leningrad 2 – encephalitis, and HSV-1 strain Leningrad 2-caused skin infection. In brain and respiratory infections the antiviral activity was manifested via the protection index, a decrease in the cumulative mortality percentage, and by the prolongation of the mean survival time. In the HSV-1 dermatitis suppression of symptomatology was observed.
Keywords: dipyridamole, interferon inducer, mice, SFV, HSV-1, influenza viruses A and B
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